‘Patchiness’ and basic cancer research: unravelling the proteases
نویسندگان
چکیده
منابع مشابه
Colorectal Cancer: Basic and Translational Research.
BACKGROUND Colorectal cancer (CRC) still accounts for high mortality and morbidity of cancer patients worldwide. Early detection screening and therapeutic management of CRC are still traditional, with some important progress including cetuximab, microsatellite instability and the concept of CRC intrinsic subtypes. SUMMARY Most achievements are derived from translational cancer research. Trans...
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With the advent of molecular targeted therapies and the development of high-throughput biotechnologies, it has become evident that progress in cancer research is largely due to the creation of multidisciplinary teams able to plan clinical trials supported by appropriate molecular hypotheses. These efforts have culminated in the identification and validation of biomarkers predictive of response,...
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چکیده ندارد.
Meeting report: Proteases, extracellular matrix, and cancer: an AACR Special Conference in Cancer Research.
Our view of the ECM and its role in cancer has substantially evolved over the last decade. It is now apparent that the ECM is much more than a physical barrier against tumor invasion. It is an integral part of the tumor microenvironment and extensively modified by proteases during malignant progression. We have begun to appreciate that these proteases do more than just degrade the ECM and allow...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2019
ISSN: 1538-4101,1551-4005
DOI: 10.1080/15384101.2019.1632639